HPV- Viral Like Particles (VLP) Vaccine, Disequilibrium between Cell Survival Signals and Apoptosis Signals, and Motor Neuron Disease HPV-VLP and signaling cascades (PI3 Kinase, Akt, GSK3b) Motor Neuron Disease, Progressive Muscular Atrophy, Amyotrophic Lateral Sclerosis and signaling cascades (PI3 Kinase, Akt, GSK3b)HPV-VLP and Motor Neuron Disease- is there a link? Akt, SMN, and motor neuron survival HPV-VLP, MyD88, Neuroprotection When iPI3 g iIP3 g iAkt g iGSK-3 -Phos g iI-2 -Phos g hPPI-1 activity which further decreases GSK Phos (this appears to become a vicious cycle and perhaps leads to self perpetuation of activation of the GSK pathway (thus loss of survival proteins c-myc and cyclin D).Can we use trophic factors to treat a potential PI3/Akt/GSK signaling problem? To further understand the mechanism of the HPV-VLPs, should we look into the syncope events after HPV vaccination